By Beth Coopman, Pharm.D.
As the final article in our three-part series on seasonal allergies and medicine, we’re examining the final component of allergy relief – eye drops. Our past articles covered allergy medicines and over-the-counter nasal sprays. These comparisons, tips and tricks should help you stay ahead of irritating and even dangerous allergy symptoms, keeping you as healthy as possible.
Store shelves are stocked with a plenty of eye-drop options. With so many choices on the market, you’re probably wondering how to be certain which one is the best for you? Like allergy pills and nasal spray, the best starting point is always letting your allergy symptoms guide you.
Allergy eye drops are absorbed directly into the eyes where they are needed. For that reason, full-body side effects are rare. In contrast, oral allergy medications are absorbed and metabolized to reach our blood stream, which can result in full-body side effects like tiredness, dry mouth, constipation, vomiting and headache.
That said, you’ll typically find three types of eye drops available:
For those with eye redness and dryness, artificial tears and saline eye wash provide a non-medicated option for lubrication and washing the allergen from the eye. All ages can use artificial tears and saline eye wash with few side effects and minimal cost which makes them good choices in pregnancy, during breastfeeding and for children with eye allergies.
In addition to refrigerating lubricating eye drops, placing an ice pack or cold compress on the eyes can also provide relief. Things to avoid include rubbing your eyes, which worsens symptoms and wearing contact lenses, which allergens stick to.
If non-medicated eye drops are ineffective, antihistamine eye drops are the next best option for itchy and watery eyes. These eye drops are valued for their ability to rapidly relieve allergy symptoms.
Mast-cell stabilizers, another eye drop drug class, have minimal side effects, can prevent allergies and are safe if used long term. Best of all, the dual action antihistamine and mast-cell stabilizer eye drops, olopatadine (Pataday®) and ketotifen (Alaway®, Zaditor®), work quickly to treat and prevent eye allergies from pet dander, pollen, ragweed and grass. Pataday® is now available over-the-counter in once-daily and twice-daily formulations.
Eye decongestants, like naphazoline, tetrahydrozoline, oxymetazoline and phenylephrine work to reduce eye inflammation and redness. These eye drops should not be used longer than 72 hours because eye redness can worsen from overuse.
NaphconA contains a decongestant and antihistamine to reduce redness, itchy and watery eyes. Lumify® is a new OTC eye drop, which reduces eye redness only.
Whichever eye drop type you decide on, here are some precautions to keep in mind when using eye drops.
Brand Name |
Generic Name |
Age Allowed |
Onset of Effect |
Peak |
Duration |
Common Side Effects |
Cost/Bottle |
Pataday® Once daily |
Olopatadine 0.2% |
≥ 2 yrs |
Rapid |
2 hrs |
24 hrs |
Headache Eye burning Eye stinging |
$19 |
Pataday® Twice daily |
Olopatadine 0.1% |
≥ 2 yrs |
Rapid |
2 hrs |
12 hours |
Headache Eye burning Eye stinging |
$16 |
Zaditor® Twice to three times daily |
Ketotifen 0.035% |
≥ 3 yrs |
Rapid |
2-4 hrs |
12 hrs |
Eye redness Headache Runny nose |
$15 |
Alaway® Twice to three times daily |
Ketotifen 0.025% |
≥ 3 yrs |
Rapid |
2-4 hrs |
12 hrs |
Eye redness Headache Runny nose |
$11 |
NaphconA® Four times daily |
Naphazoline 0.025% and Pheniramine 0.3% |
≥ 6 yrs |
Rapid |
Up to 2 hours |
6-8 hrs |
Eye redness Eye irritation Eye pain |
$11 |
Saline Eye Wash |
Varies |
All |
Rapid |
Rapid |
Varies |
Eye discharge Eye stinging |
$4-10 |
Artificial Tears |
Varies |
All |
Rapid |
Rapid |
2-4 hrs |
Eye discharge Eye stinging |
$4-10 |
Lumify® |
Brimonidine 0.025% |
≥ 5 yrs |
Rapid |
Up to 4 hrs |
8 hrs |
Itching Foreign body sensation in eye Tearing |
$12 |
*Reference: Micromedex® and pricing estimates from Walmart.com
** Cost listed is for generic product and cost decreases per dose as package size increases.
Be an informed health care consumer. Know how your prescription choices impact your plan’s costs. Ask your doctor or pharmacist about cost alternatives for your prescriptions or OTC selections. If you have any questions pertaining to this article email the pharmacy team at pharmacists@networkhealth.com.
For more information on how your Network Health plan can help with uncomfortable allergies, contact us today.